The soundtrack of ANNO: Mutationem was created by Haloweak, the music director of Vanguard Sound, who led a number of music producers to create future-filled, cyberpunk-inspired electronic music and a variety of diverse music integrated into the game's worldview; GhostFinal, also from Vanguard Sound, led a number of sound designers and audio programs to complete the game's entire sound design.
Альбом был написан Coyde / GhostFinal / Haloweak / Moto / RabbitJ и вышел 16 марта 2022 года. На саундтрек попало 46 композиций. Подборка является компиляцией оригинальной музыки. Выпуском пластинки занимался лейбл Lightning Games, Vanguard Sound.
CD 1
| 1 | Anno Muationem | | |
| 2 | Skopp | | |
| 3 | Ann's Home | | |
| 4 | Simulator | | |
| 5 | Margaritia | | |
| 6 | "The Sicilian Jar" Bar | | |
| 7 | Rum And Coke | | |
| 8 | Strangers | | |
| 9 | Backstreet Gangster | | |
| 10 | Rooftop | | |
| 11 | Loki's Mecha | | |
| 12 | Underground Base Area A | | |
| 13 | The Outcasts' Sanctuary | | |
| 14 | Water Channel | | |
| 15 | Absalom | | |
| 16 | Awaking | | |
| 17 | Beyond Vision | | |
| 18 | Bloodluster | | |
| 19 | Here They Come | | |
| 20 | Biological Research Base | | |
| 21 | Mother Grub | | |
| 22 | Mismatch | | |
| 23 | Harbour Town | | |
| 24 | "Nest" Bar | | |
| 25 | The Arena | | |
| 26 | Alone | | |
| 27 | Freighter | | |
| 28 | TR Mega Mecha | | |
| 29 | Research Base Area B | | |
| 30 | Eindersohn Mecha | | |
| 31 | Someday | | |
| 32 | Central Administration Zone | | |
| 33 | Flores and Ice | | |
| 34 | Central Intelligence Base | | |
| 35 | Behind The Shadow | | |
| 36 | Inner Consortium | | |
| 37 | Varanus Ferocious | | |
| 38 | Ephantom | | |
| 39 | Nidhogg | | |
| 40 | Last Strike | | |
| 41 | Reunion | | |
| 42 | Hilarious Whisper | | |
| 43 | Synthetic Life | | |
| 44 | Nocturne Maze | | |
| 45 | Anno Mutationem (8-bit Ver) | | |
| 46 | Retro Style | | |
